Dr. Ibrahim Suleiman Eldeen

e-mail: eldeen24@umt.edu.my

tel : +609-6683952

fax : +609-6683105

Bioactivity of Plant-Derived Molecules

Ibrahim.M.S.Eldeen. (2014), Isolation of 12 Bacterial endophytes from some mangrove plants and determination of, antimicrobial properties of the isolates and the plant extracts., International Journal of Phytomedicine, Vol 6(3).

Ibrahim.M.S.Eldeen and Mohd. A.W.Effendy (2013) Antimicrobial agents from mangrove plants and their endophytes. In :Microbial pathogens and strategies for combating them: science, technology and education. Volume .  Editor: A. Méndez-Vilas. Publisher: Formatex Research Center.Spain. 872-882. ISBN: 978-84-942134-0-3.

Y.C. Koay., K. C. Wong., H. Osman., Ibrahim M. S.Eldeen., M. Asmawi, (2013). Chemical Constituents and Biological Activities of Strobilanthes crispus L.Records of Natural Products., Records of Natural Products, Vol 7(1) : 59-64.

W.N. Tan., K.C. Wong., M. Khairuddean., Ibrahim M. Eldeen., M. Z. Asmawi., B. Sulaiman. 2012. Volatile constituents of the fruit of Garcinia atroviridis and their antibacterial and anti-inflammatory activities. Flavour and Fragrance Journal 28,2-9.DOI 10.1002/ffj.3118.

Yasodha Sivasothy, Wong Keng Chong, Abdul Hamid, Ibrahim M. Eldeen.2011. Essential oils of Zingiber officinale var. rubrum Theilade and their antibacterial activities. Food Chemistry, 124,514-517.

Ibrahim M. Eldeen, Eng-Meng. Seow, Rozaimah A., Shaida F. Sulaiman. 2010. Invitro antibacterial, antioxidant, total phenolic contents and anti-HIV-1 reverse transcriptase activities of extracts of seven Phyllanthus sp. South African Journal of Botany. S. Afr. J. Bot. (2010), doi:10.1016/j.sajb.2010.05.009.

Ibrahim.M.S. Eldeen, F.R. van Heerden and J. van Staden.2010. In vitro biological activities of niloticane, a new bioactive cassane diterpene from the bark of Acacia nilotica subsp. Kraussiana. Journal of Ethnopharmacology , 128(3),555-560.

Ibrahim. M. S. Eldeen and J.van Staden. 2008. Anti-inflammatory and anti-mycobacterial activity of leaf extracts of Coleonema album. South African Journal of Botany 74, 345-347.

Ibrahim. M. S. Eldeen and J.van Staden. 2008. Cyclooxygenase inhibition and antimycobacterial effects of extracts from Sudanese medicinal plants. South African Journal of Botany 74, 225-229.

Ibrahim.M.S. Eldeen, F.R. van Heerden and J. van Staden.2008.Termilignan B and arjunic acid from the roots of  Terminalia sericea and their biological activities. Planta Medica 74, 411-413.

2007. K. Jäger, Ibrahim.M.S.Eldeen and J.van Staden. 2007. COX-1 and -2 Activity of Rose Hip. Phytotherapy Research 21, 1251-1252.

Ibrahim.M.S. Eldeen; E. E. Elgorashi; D. A. Mulholland; J. van Staden. 2006. Anolignan B: A bioactive compound from the roots of Terminalia sericea. Journal of Ethnopharmacology 103, 135-138.

Ibrahim. M. S. Eldeen and J.van Staden. 2007. Antimycobacterial activity of some trees used in South African traditional medicine. South African journal of Botany 73, 248-251.

Ibrahim. M. S. Eldeen and J.van Staden. 2007. In vitro pharmacological properties of extracts from some trees used in Sudanese traditional medicine.  South African Journal of Botany 73, 435-440.

Ibrahim .M.S. Eldeen, F.R. van Heerden and J. van Staden.2007. Biological activities of cycloart-23-ene-3,25-diol isolated from the leaves of Trichilia dregeana.  South African Journal of Botany, Vol 73, : 366-371.

Ibrahim.M.S. Eldeen; E. E. Elgorashi; D. A. Mulholland; J. van Staden. 2006. Anolignan B: A bioactive compound from the roots of Terminalia sericea. Journal of Ethnopharmacology 103, 135-138.

Ibrahim. M. S. Eldeen, E. E. Elgorashi, J. van Staden. 2005. Antibacterial, anti-inflammatory, anti-cholinesterase and mutagenic effects of extracts obtained from some trees used in South African traditional medicine. Journal of Ethnopharmacology 102, 457-464.

RESEARCH SUMMARY

Currently, we are focusing on plants from marine ecosystems in particular our magical mangroves.  The collective noun mangrove designates an inter-tidal wetland ecosystem formed by a very special association of animals and plants in the coastal areas and river estuaries throughout the low lying tropical and sub-tropical latitudes. Mangroves are highly productive ecosystem with various important economic and environmental functions. They exist under stressful conditions such as violent environments, high concentration of moisture, high and low tides of water, and abundant living microorganisms and insects. Due to this special growth environment, mangroves produce diverse group of metabolic substances with wide range of biological activities.

Although the chemical constituents of most mangrove plants still have not been studied extensively, our investigations have led so far to the discovery of different compounds and/or fractions with prospective medicinal values.

Our current project is focused on natural products with anti-rheumatoid arthritis properties. Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of joints leading to progressive and irreversible joint destruction. This partially caused by an aggressive invasion of synovial tissue, called pannus, to local articular structure. The pannus is characterized by a synovial hyperplasia composed mainly of fibroblast-like synoviocytes (FLSs) combined with a massive infiltration of lymphocytes and macrophages. In this project we are looking for molecules that supress the up normal proliferation of fibroblast-like synoviocytes.

Apart from the mangrove plants, we are also looking at the endophytes as a rich source of bioactive entities. Endophytes are microorganisms that live in the intercellular spaces of plant tissue with no apparent damage to their host. Endophytes represent a huge diversity of microbial adaptations that have developed in special sequestered environment. This could therefore, act as a selection pressure for the development of novel metabolic pathways which may lead to exquisite end products. Thanks to the endophytic fungus Taxomyces andreana and its host plant Taxus brevifolia for the production of the taxol, the famous anti-cancer compound. Endophytes therefore, are viewed as an outstanding source of bioactive natural products that need to be fully discovered. We have isolated a number of endophytic bacterial strains that produce potential antimicrobial substances. We are looking forward to develop these agents as food preservatives.

1. Charité-University Medicine Berlin, Tissue Engineering & Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.

2. School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.