NATURAL AND SYNTHETIC PRODUCTS

02Natural products from marine invertebrates play a pivotal role in the   development of new therapeutics. Thus we develop an integrated  platform to quickly  and  reliably produce the  lead-like enhanced fractions (LLEF) from marine invertebrate which will then undergo  biological testing, isolation, purification,  and structural  elucidation of the chemical constituents to find the lead compound. The repository was established to store all of LLEF, natural and synthetic products as to develop a sustainable supply of marine natural product leads.

 

IMMUNE AND MOLECULAR THERAPEUTICS

01Sources of chemical diversity from marine organisms deposited in IMB repository will be subjected to various high throughput screening assays in the quest to determine and identify small molecules with potent biological activities. The screening platforms that  have  been  established  in  IMB  include anti-inflammatory,  anti-diabetic, anti-hypercholesterolaemia,  cytotoxity,  anti-oxidant  as  well  as  anti-fouling using target-based, cell-free, cell-based and whole organism as model systems

 

APPLICATIONS OF MARINE RESOURCES

03By using  marine  organisms  including microalgae as marine  resources,  the  main project from this  program is  focusing on the  establishment of new and sustainable  collection of marine  microorganisms for  the  discovery of  new  and  potential  drug candidates. The aim of the program is to collect and identify 2000 marine microorganisms within 5 years. Other aims of the project are to establish and sustainthe repository of identified marine microorganisms as well as to store and manage the information from identified isolates.


 

PROGRAMMES NATURAL AND SYNTHETIC PRODUCTS IMMUNE AND MOLECULAR THERAPEUTICS APPLICATIONS OF MARINE RESOURCES
TECHNOLOGY PLATFORMS ·         BIOTA

·         NATURAL PRODUCT LIBRARY

·         NMR

·         HPLC/GCMS/LCMS

·         HP-TLC

·         PROTEOMIC

·         GENOMICS

·         HTS

·         HCS

·         PROTEIN PURIFIER

·         MARINE MICROBIAL CULTURE COLLECTION

·         MICROBIAL ID PLATFORM

·         GENOMICS

·         BIOINFORMATICS

ENABLERS ·         GOOD SCIENCE PRACTICE

·         ISO 17025

·         NATIONAL BIOINFORMAICS SYSTEM (NABTICS)

FLAGSHIP PROGRAMMES MARINE DRUG DISCOVERY
SPECIFIC PROJECT ·         COLLECTION OF MARIE ORGANISM

·         PREPARATION OF BIOTA

·         PREPARATIONOF NATURAL PRODUCTS

·         SYNTHETIC OF DERIVATIVES OF NATURAL COMPOUNDS

·         ROLES OF HSP70 IN IMMUNE SYSTEM

·         SCREENING CAMPAIGN USING HTS

·         ROLES OF MARINE BIOPRODUCTS AS ADJUVANTS

·         USE OF IN VIVO MODELS IN DRUG DISCOVERY

·         COLLECTION AND CHARACTERISATION OF MARINE MICROORGANISM/ RESOURCES

·         PRODUCTION OF BIOPRODUCTS (BIOFUEL/ BIOPLASTICS/ DIAGNOSTIC KITS)

·         ROLES OF MARINE MICROBS IN BIOREMEDIATION