NATURAL AND SYNTHETIC PRODUCTS
Natural products from marine invertebrates play a pivotal role in the development of new therapeutics due to their rich chemical diversity. The primary function of this research programme is to spearhead the production of enhanced fractions and small molecules from the prepared powdered biota, which are then deposited in IMB’s natural and synthetic product repository. In addition, researchers are also involved in the isolation of compounds from the hit enhanced fractions and structural elucidation of the isolated compounds. Synthesis of derivatives based on the identified natural compounds also forms one of the research areas under this programme. In addition, this programme is also looking into the possibility of commercialising the natural products for the enhancement of human health.
Assoc Prof. Dr. Habsah Mohamad
|Dr. Yosie Andriani Hs
IMMUNE AND MOLECULAR THERAPEUTICS
This programme is responsible for the development of high-throughput screening assays using cell-free, cell-based and whole organism model systems in order to serve as platforms to interrogate the small molecules prepared from Natural and Synthetic Products research programme. Such screening platforms are being used to search for potential hits for diabetes, atherosclerosis, cancer anti-inflammatory, anti-infective, anti-fouling as well as anti-oxidative agents. This programme is also dedicated to undertake fundamental research to elucidate the molecular mechanisms and pathways during infection and disease development using artemia, rodents, marine organisms as well as cell culture as the model systems. The use of extracts prepared from marine organisms as adjuvant for vaccine development also forms one of the priority areas. Realising the importance of bioinformatics in the era of genomics, that area has been identified as an emerging area under this programme
Prof. Dr. Tengku Sifzizul Tengku Muhammad
|Assoc. Prof. Dr. Yeong Yik Sung
Prof. Dr. Mohd. Effendy Abd. Wahid
APPLICATION OF MARINE RESOURCES
A vast number of marine resources can convert simple substrates into products that the organisms need for growth and survival. One of the main tasks is to carry out sustainable collection and identification of marine microorganisms with vast potentials for the production of secondary metabolites as drug candidates. The isolated marine microbes and secondary metabolites are then deposited into the respective microbial, natural and synthetic product repositories. In addition, researchers are also actively identifying new algae as important sources of high value bioproducts for edible (polyunsaturated fatty acids, anti-oxidative agents) and non-edible (biofuels) applications. Various tools ranging from molecular biology to bioprocess are being utilised to increase the production of oils in algae. Beside algae, researchers are also looking into the applications of bioproducts from horseshoe crab and seahorse.
Assoc. Prof. Dr. Noraznawati Ismail
|Assoc. Prof. Dr. Azmuddin Abdullah
|Dr. Jasnizat Saidin
Prof. Dr. Fadzillah@Adibah Abdul Majid
|Assoc Prof. Dr. Mohd Zul Helmi Rozaini